The Chi lab investigates immunobiology and cancer immunology, by focusing on metabolic regulation of the immune system (immunometabolism) and its implications in cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in understanding the metabolic programs (e.g., amino acid and lipid metabolism), signaling pathways (e.g., mTOR and nutrient-induced signaling), and systems-level regulatory networks (e.g., protein-protein or driver gene-target gene interactions) that regulate basic T cell and dendritic cell biology and antitumor immunity. To this end, we apply interdisciplinary strategies by integrating immunological and genetic approaches with cutting-edge systems immunology and functional genomics tools, including in vivo CRISPR screening, single-cell transcriptomics, proteomics, metabolomics, and network reconstruction. Former trainees of the Chi lab have been principal investigators in multiple academic institutions. Please also see the following articles published over the past four years for additional information: Nature 624:154 (2023); Nature 620:200 (2023); Nature Immunology 24:1735 (2023); Nature Reviews Immunology 23:363 (2023); Nature 607:135 (2022); Nature Cell Biology 24:1642 (2022); Immunity 55:14 (2022); Nature Chemical Biology 18:470 (2022); Nature 600:308 (2021); Nature 595:724 (2021); Nature 591:306 (2021); and Cell 184:1245 (2021).

St. Jude Children's Research Hospital, ranked as the best children's hospital for pediatric cancer, offers an exceptional research and training environment with state-of-the-art facilities, along with competitive salaries and excellent benefits, to postdoctoral fellows. To find out more about our benefits for postdocs, check out this .

Highly motivated individuals with a recent Ph.D. in immunology or cell biology and publication records (minimum of one-first author publication in a peer-reviewed journal) are encouraged to apply for the open position ().

Diversity, Equity and Inclusion

St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. .

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

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